M.D. Wheatley and W.S. McCulloch
The effect of intravenous sodium cyanide (dose, in mg./kg., injected during seven seconds) on the glass electropotential (H+), noble-metal potential (O/R), oxygen tension (O2) and activity of exposed cortex (ECG) and the electrocardiogram (EKG), were recorded simultaneously in cats under dihydro-erythroidine hydrobromide, artificially ventilated.
All doses gave flattening of ECG and vagal slowing of the heart.
1) 0.1 to 0.4 decreased (H+) and increased (O2) for less than a minute. 2) 0.3 to 0.7 gave the above changes, then, for 5 to 40 minutes, increased (H+) and decreased (O2) with secondary slowing of the heart. 3) 0.6 to 1.2 gave the same as except that the heart, after 20 to 70 minutes of block and anoxic changes, returned before the ECG when (H+) decreased and (O2) increased beyond control values. 4) 1.0 to 1.6 gave the same as except that the ECG never returned and (O2) fell suddenly from a high value when edema occluded circulation at the tentorial margin.
All (O/R) changes were referable to change of (H+) and to the circulation, indicating that the (O/R) system communicating with the noble- metal electrode was not cyanide-sensitive.
Except for obscuration by decreased circulation due to action of cyanide on the heart, it appears that decrease or absence of cortical activity permitted (O2) to rise and (H+) to fall.
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Keywords: Potential, Cyanide, Changes, Truth, Electro potential, Action, Looms, Dose, Noble-Metal
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